Seto Kaiba is the majority shareholder and President of his own multi-national company, KaibaCorp, who aims to become the world's greatest player of the Duel Monsters card game. To accomplish this goal, he must defeat his arch-rival, Yugi Muto. He is largely considered an anti-hero, as his motives are usually ego-centric, but in several cases towards a good cause.

Among one of the recurring plots in Yu-Gi-Oh! Duel Monsters is Seto Kaiba being forced to deal with either people adversely affected by Gozaburo Kaiba's actions wanting to take their revenge on Seto Kaiba, or people from within KaibaCorp attempting to take over the corporation.